spdr · full holdings · sec n-port

XBI holdings

State Street SPDR S&P Biotech ETF. XBI holds 150 securities. The 10 largest are 13% of the fund, and 44 names carry half of it.

Holdings as of June 30, 2026 · source: SEC Form N-PORT, filed August 28, 2026

concentrationdownload csv

holdings150

top 10 weight13.3%

names to reach half44

behaves like110 equal stocks

01Holdings

The 100 largest, in order

xbi holdingslargest 100 of 150

#companysectorweightrunning

1APAPGEApogee Therapeutics Inc—1.49%1.49%1.5%

MRNAModerna IncHealth Care1.41%1.41%2.9%

3TWTWSTTwist Bioscience CorpHealth Care1.41%1.41%4.3%

4ORORKAOruka Therapeutics IncHealth Care1.38%1.38%5.7%

5KYKYMRKymera Therapeutics IncHealth Care1.36%1.36%7.0%

6VKVKTXViking Therapeutics Inc—1.30%1.30%8.4%

7PRPRAXPraxis Precision Medicines IncHealth Care1.29%1.29%9.6%

8ERERASErasca IncHealth Care1.27%1.27%10.9%

9RVRVMDRevolution Medicines IncHealth Care1.20%1.20%12.1%

10RYRYTMRhythm Pharmaceuticals IncHealth Care1.20%1.20%13.3%

11CGCGONCG oncology IncHealth Care1.20%1.20%14.5%

12SLSLSSELLAS Life Sciences Group IncHealth Care1.19%1.19%15.7%

13PCPCVXVaxcyte IncHealth Care1.19%1.19%16.9%

14DNDNTHDianthus Therapeutics IncHealth Care1.18%1.18%18.1%

15CYCYTKCytokinetics IncHealth Care1.18%1.18%19.3%

16NTNTRANatera IncHealth Care1.16%1.16%20.4%

17SRSRRKScholar Rock Holding CorpHealth Care1.16%1.16%21.6%

18ROROIVRoivant Sciences LtdHealth Care1.16%1.16%22.7%

19MIMIRMMirum Pharmaceuticals IncHealth Care1.16%1.16%23.9%

20COCOGTCogent Biosciences IncHealth Care1.14%1.14%25.0%

21RARAREUltragenyx Pharmaceutical IncHealth Care1.14%1.14%26.2%

22TVTVTXTravere Therapeutics IncHealth Care1.13%1.13%27.3%

23ALALKSAlkermes PLCHealth Care1.11%1.11%28.4%

24KRKRYSKrystal Biotech IncHealth Care1.10%1.10%29.5%

25CECELCCelcuity IncHealth Care1.10%1.10%30.6%

26RLRLAYRelay Therapeutics IncHealth Care1.10%1.10%31.7%

27SYSYRESpyre Therapeutics IncHealth Care1.10%1.10%32.8%

28TGTGTXTG Therapeutics IncHealth Care1.09%1.09%33.9%

29BEBEAMBeam Therapeutics IncHealth Care1.08%1.08%35.0%

30ININSMInsmed IncHealth Care1.08%1.08%36.1%

31PTPTGXProtagonist Therapeutics IncHealth Care1.07%1.07%37.1%

32ARARWRArrowhead Pharmaceuticals Inc—1.07%1.07%38.2%

33VEVERAVera Therapeutics IncHealth Care1.06%1.06%39.3%

VRTXVertex Pharmaceuticals IncHealth Care1.06%1.06%40.3%

35MDMDGLMadrigal Pharmaceuticals Inc—1.06%1.06%41.4%

ABBVAbbVie IncHealth Care1.04%1.04%42.4%

BIIBBiogen IncHealth Care1.03%1.03%43.4%

38PTPTCTPTC Therapeutics IncHealth Care1.03%1.03%44.5%

39HAHALOHalozyme Therapeutics Inc—1.03%1.03%45.5%

40UN—uniQure NV—1.03%1.03%46.5%

41BBBBIOBridgebio Pharma Inc—1.02%1.02%47.6%

42CRCRSPCRISPR Therapeutics AGHealth Care1.02%1.02%48.6%

43IBIBRXImmunityBio IncHealth Care1.02%1.02%49.6%

44SMSMMTSummit Therapeutics Inc—1.01%1.01%50.6%

45IOIONSIonis Pharmaceuticals Inc—1.00%1.00%51.6%

INCYIncyte CorpHealth Care1.00%1.00%52.6%

AMGNAmgen IncHealth Care0.99%0.99%53.6%

48NBNBIXNeurocrine Biosciences IncHealth Care0.97%0.97%54.6%

GILDGilead Sciences IncHealth Care0.96%0.96%55.5%

REGNRegeneron Pharmaceuticals IncHealth Care0.96%0.96%56.5%

51EXEXELExelixis Inc—0.96%0.96%57.5%

52ALALNYAlnylam Pharmaceuticals IncHealth Care0.96%0.96%58.4%

53BMBMRNBioMarin Pharmaceutical Inc—0.94%0.94%59.4%

54ACACADACADIA Pharmaceuticals IncHealth Care0.94%0.94%60.3%

55NU—Nuvalent Inc—0.93%0.93%61.2%

56IMIMVTImmunovant IncHealth Care0.92%0.92%62.2%

57UTUTHRUnited Therapeutics CorpHealth Care0.92%0.92%63.1%

58NTNTLAIntellia Therapeutics IncHealth Care0.91%0.91%64.0%

59GRGRALGRAIL IncHealth Care0.91%0.91%64.9%

60BCBCRXBioCryst Pharmaceuticals IncHealth Care0.89%0.89%65.8%

61CA—Catalyst Pharmaceuticals Inc—0.87%0.87%66.7%

62DYDYNDyne Therapeutics IncHealth Care0.86%0.86%67.5%

63TNTNGXTango Therapeutics IncHealth Care0.84%0.84%68.4%

64DNDNLIDenali Therapeutics IncHealth Care0.83%0.83%69.2%

65VCVCYTVeracyte IncHealth Care0.82%0.82%70.0%

66IDIDYAIdeaya Biosciences IncHealth Care0.80%0.80%70.8%

67RXRXRXRecursion Pharmaceuticals IncHealth Care0.76%0.76%71.6%

68SRSRPTSarepta Therapeutics IncHealth Care0.75%0.75%72.3%

69RCRCUSArcus Biosciences IncHealth Care0.74%0.74%73.1%

70SNSNDXSyndax Pharmaceuticals IncHealth Care0.72%0.72%73.8%

71ARARQTArcutis Biotherapeutics IncHealth Care0.71%0.71%74.5%

72MLMLYSMineralys Therapeutics IncHealth Care0.71%0.71%75.2%

73CLCLDXCelldex Therapeutics IncHealth Care0.70%0.70%75.9%

74AGAGIOAgios Pharmaceuticals IncHealth Care0.69%0.69%76.6%

75VRVRDNViridian Therapeutics IncHealth Care0.67%0.67%77.3%

76NVNVAXNovavax IncHealth Care0.66%0.66%77.9%

77IRIRONDisc Medicine IncHealth Care0.65%0.65%78.6%

78ADADMAADMA Biologics IncHealth Care0.61%0.61%79.2%

79IMIMNMImmunome IncHealth Care0.59%0.59%79.8%

80PVPVLAPalvella Therapeutics IncHealth Care0.58%0.58%80.4%

81IOIOVAIovance Biotherapeutics IncHealth Care0.56%0.56%80.9%

82ABABSIAbsci CorpHealth Care0.56%0.56%81.5%

83NRNRIXNurix Therapeutics IncHealth Care0.56%0.56%82.0%

84KOKODKodiak Sciences IncHealth Care0.54%0.54%82.6%

85BHBHVNBiohaven LtdHealth Care0.53%0.53%83.1%

86VCVCELVericel CorpHealth Care0.49%0.49%83.6%

87ANANABAnaptysBio IncHealth Care0.49%0.49%84.1%

88CACAPRCapricor Therapeutics IncHealth Care0.49%0.49%84.6%

89STSTOKStoke Therapeutics IncHealth Care0.48%0.48%85.1%

90GLGLUEMonte Rosa Therapeutics IncHealth Care0.48%0.48%85.5%

91VIVIRVir Biotechnology IncHealth Care0.47%0.47%86.0%

92PUPURRHyperliquid Strategies IncHealth Care0.46%0.46%86.5%

93TYTYRATyra Biosciences IncHealth Care0.41%0.41%86.9%

94CRCRVSCorvus Pharmaceuticals IncHealth Care0.41%0.41%87.3%

95CGCGEMCullinan Therapeutics IncHealth Care0.40%0.40%87.7%

96PGPGENPrecigen IncHealth Care0.38%0.38%88.1%

97ININBXInhibrx Biosciences IncHealth Care0.35%0.35%88.4%

98TSTSHATaysha Gene Therapies IncHealth Care0.35%0.35%88.8%

99ARARDXArdelyx IncHealth Care0.35%0.35%89.1%

100AVAVTXAvalo Therapeutics IncHealth Care0.35%0.35%89.5%

The other 50 are in the full CSV.

02Sectors

Where the money sits

sectorsshare of the fund

Health Care85.9%

Not classified14.0%

03Overlap

The funds that hold the most of the same XBI money

overlap66 funds compared

IWM9.1%ARKK7.2%XLV7.1%VB5.3%USMV4.4%COWZ3.7%IJR3.4%IJH3.1%JEPI3.1%VTV3.0%

04Questions

XBI holdings: what people ask

questions4 answered

How many stocks does XBI hold?

150 securities, according to the Form N-PORT SPDR filed with the SEC on August 28, 2026, holdings as of June 30, 2026.

What are XBI's top 10 holdings?

APGE, MRNA, TWST, ORKA, KYMR, VKTX, PRAX, ERAS, RVMD and RYTM. Together they are 13% of the fund.

How concentrated is XBI?

44 of its 150 holdings make up half of the fund. By weight it behaves like 110 equally weighted stocks.

Which ETFs overlap most with XBI?

IWM (9.1%), ARKK (7.2%) and XLV (7.1%), measured on the full holdings of each fund.

Own XBI?Import your positions and see what your funds hold together, company by company, with the fees you pay on each.Import my portfolio

Weights are from the fund's Form N-PORT, the report every US fund files with the SEC each quarter, as of June 30, 2026 and filed on August 28, 2026. The SEC publishes it up to 60 days after that date, so the fund may have traded since. They are a share of the fund's net assets; cash and derivatives (6.02%) are left out of the list. This page describes what the fund holds; it is not investment advice.